Retatrutide (LY3437943), 99.9% Purity Peptide 1G Lab Use Only. A must-have peptide for excess body size without the adverse effect of oz-face and oz-butt, at the final stage of a clinical trial.
- Retatrutide: It's a novel triple agonist that mimics three hormones: GLP-1, GIP, and glucagon. This combination promotes significant body size reduction, improves blood sugar control, and offers other metabolic benefits.
- Sermorelin: It's a growth hormone-releasing hormone (GHRH) analog. It stimulates the pituitary gland to release natural human growth hormone (hGH), potentially leading to increased muscle mass, improved sleep, and enhanced energy levels.
Current Research: Retatrutide is the first triple agonist peptide targeting the Glucagon, GLP-1, and GIP receptors (3G), the EC50 values are 5.79 nM, 0.0643 nM, and 0.775 nM, respectively [1].
Among its predecessors, Liraglutide (Victoza, Saxenda), Exenatide (Byetta), Semaglutide (Ozempic, Rybelsus, Wegovy), Lixisenatide (Adlyxin), and Dulaglutide ( Trulicity) are GLP-1 receptor agonists, Tirzepatide (Mounjaro) is a GLP-1/GIP dual receptor co-agonist. Survodutide is a Glucagon/GLP-1 dual receptor co-agonist.
Retatrutide is administered subcutaneously, with a half-life of 6 days, and therefore can be injected weekly [2]. After 48 weeks, Retatrutide achieved 24.2% weight loss in obese or overweight patients and produced 17% weight loss in diabetic patients, making it arguably the most powerful pipeline today. In addition, Retatrutide also achieved up to 86% reduction in liver fat in patients with NASH (non-alcoholic steatohepatitis) [2].
A 48-week phase 2 obesity study demonstrated weight reductions of 22.8% and 24.2% with retatrutide 8 and 12 mg, respectively. The liver fat (LF) reduction at 24 weeks was -42.9% (1 mg), -57.0% (4 mg), -81.4% (8 mg), -82.4% (12 mg), and +0.3% (placebo)[3].
Storage: This peptide will normally be delivered in lyophilized form and stored in a freezer at or below -20 °C. For more details, please refer to the manual:
The offer is for 1 gram of Sermorelin and 1 gram of Retatrutide. Total size of 2 grams. Can be sent individually without blending them together.